Moloko were an English-Irish music duo from Sheffield, England. The duo consisted of vocalist Róisín Murphy and producer Mark Brydon.

Murphy had no prior professional experience as a singer when Moloko was formed. Brydon had previously worked on music as a producer with musicians such as Boy George and Cabaret Voltaire on releases from the 1990s. In 1994, the two met at a party in Sheffield, where Murphy approached Brydon with the chat-up line, "Do you like my tight sweater? See how it fits my body!" Its first sentence became their début album's title, recorded while Murphy and Brydon had begun dating. The name Moloko comes from the narcotic-filled milk drink, Moloko Plus, in the Anthony Burgess novel A Clockwork Orange, based on the Russian for milk, "??????" ("moloko").

The group signed to Echo Records and released their single "Where Is the What If the What Is in the Why?" The group's debut album Do You Like My Tight Sweater? was released in 1995. The group toured with Pulp following the release.

The single "Fun for Me" was featured prominently on the Batman & Robin soundtrack and received radio airplay and strong MTV rotation. It reached no. 4 in the US Dance chart.

After Moloko finished the tour, they built a home studio and recorded their second album, titled I Am Not a Doctor, which was released in 1998 in the United Kingdom. The album wasn't a success, reaching only no. 64 in the UK album chart. However, a Boris Dlugosch remix of "Sing It Back", the third single from the album that originally failed to reach the Top 40 in the UK Singles Chart, was a huge hit, reaching no. 4 in the UK chart and no. 1 in the US Dance Chart.

Their third album Things to Make and Do was released in the year 2000 and reached no. 3 in the UK album chart. The first single, "The Time Is Now" was their biggest hit, charting at no. 2 in the charts.

Their 2003 album Statues produced two hit singles, "Familiar Feeling", which reached no. 10 in the UK, and "Forever More", which reached no. 17. Brydon and Murphy ended their romantic relationship after the album's release and, following a tour, disbanded the group.